Global trends in population growth and rising economic prosperity are expected to increase the demand for energy, food and water, with more severe impact in fast-growing economies, such as in several African countries, which are experiencing unprecedented growth rate. Significant investments on large dams are therefore likely to increase in the next decades, in order to support the production of clean energy and extensive irrigation projects. Without a proper and state-of-the-art assessment of development pathways, this may compromise the sustainable use of natural resources. Moreover, pressures on natural resources will be exacerbated when solutions to resource constraints in one area of the world place strains on another area. The constraints on water, energy, and food, particularly in fast growing African countries, could well hamper economic development, lead to social and geopolitical tensions, and cause lasting environmental damage. The overall objective of DAFNE is to establish a decision-analytic framework (DAF) for Participatory and Integrated Planning. The DAF is a multi-step procedure that will enable the extensive, quantitative analysis of the anticipated effects of alternative planning options on the broad range of heterogeneous and often competing interests in transboundary river basins ultimately facilitating comparison and negotiation based on (a) active engagement of stakeholders in the process from the outset of the project, and (b) integration of multiple and diverse international and local academic expertise ranging from natural sciences, water engineering, and environmental economics, to water governance and laws in order to develop tools to facilitate social understanding of the impact and support comparative analysis of the alternative through negotiations.